超声波激活的压电丝-PVDF水凝通过NRF2信号来重新编程骨质免疫微环境,以加速骨再生
Guokang Mo1, Lang Qing2, Cheng Zhang1
1Department of Rehabilitation Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
Materials today. Bio
|February 9, 2026
概括
这项研究引入了一种可注射,超声响应的水凝,它使用丝纤维素和聚乙烯化物来促进骨再生. 智能生物材料激活细胞通路,促进骨缺陷的愈合.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 组织工程是组织工程.
背景情况:
- 骨缺陷存在重大临床挑战,原因是骨再生有限,生物材料不足.
- 目前的生物材料缺乏有效修复骨所需的动态电机信号.
研究的目的:
- 开发一种可注射,响应超声波的压电液凝,用于增强骨再生.
- 为了使丝纤维蛋白的结构适应性与聚乙烯化物的生物电活性产生协同作用.
主要方法:
- 通过使用甲化丝纤维素 (SM) 进行紫外线触发的交叉连接和冷解聚乙烯化物 (PVDF) 纳米纤维用于压电,设计了一种水凝.
- 研究了超声波刺激对PVDF产生电信号,激活NRF2抗氧化途径的影响.
- 评估了 *在实验室* 对巨细胞两极分化,脂肪衍生的介质干细胞 (ADSC) 的骨质分化和血管生成的影响.
- 用微型CT和组织学分析评估*in vivo*关键大小的大鼠股骨缺陷的骨再生.
主要成果:
- 对PVDF组件的超声波刺激产生了电信号,激活了NRF2通路并消除了氧化应激.
- 水凝促进了M2巨细胞的两极分化,增强了ADSC骨质分化,并刺激了血管生成 *in vitro*.
- *体内*研究表明,在大小临界的大腿部缺陷中,大鼠有显著的骨再生.
结论:
- 开发的压电水凝平台通过重复骨的电机免疫轴,有效地促进骨再生.
- 这种智能生物材料为治疗复杂的骨缺陷提供了一个范式的转变,通过动态调节氧化还原稳定,免疫反应和组织重塑来调节复杂的骨缺陷.
- 超声波触发的压电和丝纤维蛋白生物活性的整合解决了骨组织工程中的未满足需求.
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