纳米酶用于精确治疗肝细胞癌
Shu Feng1, Ying Xuan1, Hong Jin1
1Shengjing Hospital, China Medical University, Liaoning, 110004, China.
Materials today. Bio
|February 9, 2026
概括
工程纳米酶通过积极向瘤微环境 (TME) 为治疗肝细胞癌 (HCC) 提供了一种新的方法. 本综述探讨了纳米酶策略,用于对抗HCC的协同抗效应.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 在瘤学瘤学.
背景情况:
- 肝细胞癌 (HCC) 由于异质性,复发和治疗耐药性而带来了重大临床挑战.
- 工程纳米酶,具有催化功能的纳米材料,正在成为活性治疗剂.
- 纳米酶可以操纵瘤微环境 (TME) 以产生局部反应性氧物种 (ROS) 和调节细胞死亡.
研究的目的:
- 系统地审查用于肝细胞癌 (HCC) 治疗的纳米酶策略.
- 探索纳米酶在催化疗法,免疫疗法和HCC光热疗法中的潜力.
- 讨论挑战,并为未来的纳米酶在HCC治疗的发展提供见解.
主要方法:
- 在HCC中纳米酶应用的系统审查.
- 纳米酶机制的分析,包括ROS生成和TME调制.
- 讨论综合组合平台的协同作用的抗瘤效应.
主要成果:
- 纳米酶在催化疗法,纳米酶增强免疫疗法和HCC的光热疗法中显示出潜力.
- 纳米酶对TME的操纵可以导致局部ROS生成和调节的细胞死亡.
- 组合平台显示出对HCC的协同抗瘤效应的能力.
结论:
- 纳米酶策略对推进HCC治疗范式具有重大前景.
- 解决代谢异质性和生物相容性等挑战对于临床翻译至关重要.
- 下一代纳米酶的合理设计可以加快它们融入多学科HCC治疗框架.
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