接种SARS-CoV-2疫苗后的内分泌疾病:一个全面的系统审查
Cielo Cinthya Calderon-Hernandez1,2, Nelson Luis Cahuapaza-Gutierrez1,2, Tatiana Vanessa Villavicencio-Escudero1
1Universidad Científica del Sur, Lima, Perú.
Clinical and experimental vaccine research
|February 9, 2026
概括
接种COVID-19疫苗与新的内分泌疾病有关,主要是甲状腺疾病,如亚急性甲状腺炎和格雷夫斯病. 虽然并没有证明因果关系,但接种疫苗的好处超过了潜在的风险.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 冠状病毒疾病2019 (COVID-19) 疫苗的广泛使用引发了有关潜在不良影响的疑问.
- 内分泌疾病代表了一类潜在的疫苗接种后并发症,需要进行彻底调查.
研究的目的:
- 系统地审查和分析COVID-19疫苗接种后新出现的内分泌疾病的现有证据.
- 综合关于与COVID-19疫苗相关的内分泌疾病的类型,频率和临床结果的数据.
主要方法:
- 使用主要科学数据库 (PubMed,Scopus,Embase,Web of Science) 进行了系统的文献审查.
- 研究质量和偏差风险使用既有工具 (Joanna Briggs研究所,纽卡斯尔-太华规模) 进行了评估.
- 使用SPSS 25.0.0.进行统计分析.
主要成果:
- 在接种疫苗后,共有245名患有内分泌疾病的患者被确定.
- 甲状腺疾病,特别是亚急性甲状腺炎和格雷夫斯病,是最常见的 (70.6%).
- 其他报告的疾病包括1型糖尿病,上腺和垂体疾病. 大多数病例发生在第一剂疫苗接种后的妇女身上,主要是使用mRNA疫苗. 生育研究显示,没有显著的不良影响. 临床结果通常是有利的,没有报告的死亡率.
结论:
- 虽然在COVID-19疫苗接种后报告了内分泌系统疾病,但最终的因果关系仍未确立.
- 接种COVID-19疫苗的好处明显超过了内分泌学并发症的潜在风险.
- 临床医生应保持对疫苗接种后潜在的内分泌表现的认识.
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