植物衍生生物活性纳米结构的自组装在中国传统医学中
Hongzheng Zhu1, Mingyuan Liu1, Zemin Wang1
1Jiangsu Key Laboratory for Pharmacology and Safety Research of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
iScience
|February 9, 2026
概括
传统中医药 (TCM) 中的植物化合物自组装成纳米粒子,改善药物输送. 本综述探讨了这些自然纳米结构背后的科学,以提高治疗潜力.
科学领域:
- 超分子化学 超分子化学
- 药理学 药理学是指药理学的学科.
- 材料科学 材料科学 材料科学
背景情况:
- 传统中医 (TCM) 通过复杂的调节机制,利用植物衍生化合物产生治疗效果.
- 在TCM中的生物活性成分具有在生理条件下自组装成纳米结构的内在能力.
研究的目的:
- 审查具有代表性的植物性小分子 (类,多,类) 的自我组装行为.
- 讨论这些自组装纳米结构的结构特征,相互作用机制和特征.
- 突出自我组装纳米结构的好处,以提高溶解性,稳定性,生物可用性和药物输送.
主要方法:
- 关于植物衍生小分子自我组装研究的文献综述.
- 对分子架构和驱动自我组装的非共价相互作用机制的分析.
- 对自组装纳米结构的实验性表征策略的讨论.
主要成果:
- 类,多类和类的自我组装成各种纳米结构 (纳米颗粒,微粒,水凝) 是一个常见的现象.
- 与自由分子相比,这些自组装的纳米结构显示了增强的物理化学特性和治疗性能的表现.
- 自组装行为与分子结构和环境响应性密切相关.
结论:
- 植物化合物的自我组装为TCM疗效提供了材料基础.
- 整合超分子化学原理与TCM药理学可以指导植物衍生纳米药物的合理设计.
- 这种方法在开发新型纳米疗法方面具有显著的翻译潜力.
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