核糖体生物发生率,对抑制rRNA合成的化疗药物敏感性的参数

Davide Treré1,2, Lorenzo Montanaro1,2, Massimo Derenzini3

  • 1IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Oncology reviews
|February 9, 2026
PubMed
概括

针对核糖体生物生成 (RiBi) 的癌症化疗药物通过抑制MDM2.2来起作用. 高水平的RiBi增强了药物的有效性,而低水平或突变可能需要组合疗法来有效地杀死癌细胞.

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