流感A病毒与SARS-CoV-2感染和情绪障碍之间的关联
Yanling Xiang1,2, Wanqi Wang1,2, Jinyi Zhu1,2
1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510180, China.
Brain, behavior, & immunity - health
|February 9, 2026
概括
流感A病毒 (IAV) 和SARS-CoV-2感染可以影响中枢神经系统,增加情绪障碍 (如焦虑和抑郁症) 的风险. 本综述探讨了这些感染和心理健康状况之间的双向关系.
科学领域:
- 传染性疾病 传染性疾病
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 急性呼吸道感染 (ARI),主要是病毒性,在全球范围内很常见.
- 由于可传播性和致病性,A型流感病毒 (IAV) 和SARS-CoV-2对公共卫生构成了重大挑战.
- 新出现的证据将IAV和SARS-CoV-2与中枢神经系统 (CNS) 的参与联系起来,可能引发或加剧情绪障碍.
研究的目的:
- 审查IAV和SARS-CoV-2感染与情绪障碍并发症的临床特征.
- 阐明病毒感染和心理健康状况之间的复杂双向关系.
- 提出一个新的框架,区分影响这种共同疾病的外部 (压力) 和内部 (生物) 途径.
主要方法:
- 关于IAV,SARS-CoV-2和情绪障碍的现有证据的文献综述.
- 分析中枢神经系统参与和免疫失调的拟议机制.
- 综合发现,以分类病因途径.
主要成果:
- IAV和SARS-CoV-2可以引起神经侵袭和炎症,导致焦虑和抑郁.
- 患有情绪障碍的人可能对严重的IAV和SARS-CoV-2感染的易感性增加.
- 确定了两个不同的途径:心理压力和生物因素 (免疫/肠道微生物群).
结论:
- 呼吸道病毒感染和情绪障碍之间的并发症是显著的,影响患者的结果和医疗保健.
- 了解双重途径 (压力与生物) 对于有针对性的干预至关重要.
- 本综述为未来对病毒感染中神经炎症和心理健康的研究提供了框架.
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