葡萄糖样-1受体激活剂和肺炎和术后住院的风险在接受胃肠内镜检查的患者中
Chunyuan Qiu1,2, Qiaoling Chen2, Stephanie Tovar2
1Department of Anesthesiology, Kaiser Permanente Baldwin Park Medical Center, Baldwin Park, California.
Gastro hep advances
|February 9, 2026
概括
类似葡萄糖-1受体激动剂 (GLP-1RA) 的使用没有增加胃肠内镜后肺炎或住院的风险. 这项研究发现,在手术镇静期间继续使用GLP-1RA无显著不良事件.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 麻醉学 麻醉学
背景情况:
- 在程序镇静和麻醉期间使用类似葡萄糖-1受体激动剂 (GLP-1RA) 存在安全问题.
- GLP-1RAs越来越多地用于2型糖尿病和肥胖症,导致更多服用这些药物的患者接受手术.
研究的目的:
- 评估GLP-1RA使用与肺炎和紧急护理,急诊室访问和住院的术后风险之间的关联.
- 评估在胃肠道内镜手术期间继续GLP-1RA治疗的安全性.
主要方法:
- 采用了一种倾向匹配的回顾性队列研究设计.
- 接受胃肠内镜检查的活跃GLP-1RA使用的患者与对照组相比为1:4.
- 结果包括术后肺炎,住院,紧急护理访问,急诊室访问和30天死亡率.
主要成果:
- 该研究包括3825名GLP-1RA使用者和14920名对照者,主要是结肠镜检查.
- 在活性GLP-1RA使用和术后肺炎 (OR 0.56) 或30天住院 (OR 0.76) 之间没有发现显著的关联.
- 对于紧急护理访问,急诊室访问或术后7天或30天的死亡率,没有观察到任何显著的关联.
结论:
- 不间断使用GLP-1RA与接受胃肠内镜与镇静治疗的患者的重大不良事件无关.
- 这些发现表明,在接受这些手术的患者中,GLP-1RA治疗可以安全地继续.
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