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Updated: Feb 10, 2026

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作为一种预测工具的血栓栓塞事件后的额外的创伤后的Thrombbelastography:第二次分析的PREVENT-CLOT
Cory K Mayfield1, Nathan N O'Hara2, Prism S Schneider3
1Keck School of Medicine of the University of Southern California, Los Angeles, California.
JB & JS open access
|February 9, 2026
概括
在入院血栓激活图 (TEG) 上,最大幅度升高并不能预测骨科创伤患者的静脉血栓栓塞 (VTE). 然而,对TEG反应时间的增加与VTE风险的增加有悖论的关联.
科学领域:
- 整形外科手术 整形外科手术
- 创伤护理 创伤护理
- 血液学 血液学 血液学
背景情况:
- 静脉血栓塞栓症 (VTE) 是骨科创伤患者患病和死亡的重要原因.
- 血栓形成显微镜 (TEG) 可以识别高凝血能力,并预测受伤后的静脉瘤风险.
- 之前的研究表明,TEG上最大幅度 (MA) 的升高与VTE风险增加有关.
研究的目的:
- 调查是否入院时的TEG分析预测了严重四肢创伤患者的术后血栓栓塞事件.
- 测试假设,在初始TEG上升的MA与增加的VTE风险相关.
主要方法:
- 多中心PREVENT CLOT随机试验的二次分析.
- 包括肢体,骨盆或骨骨折的成年患者.
- 使用回归分析评估了入院TEG值和术后VTE之间的关联.
主要成果:
- 1183名患者接受了TEG入院; 3.97%的患者经历了手术后的VTE.
- 在高MA值 (MA≥65,≥69,或≥72) 的VTE频率中没有显著差异.
- 更高的入院TEG反应时间 (R-时间) 与VTE显著相关 (p <0.01);R-时间≥2.0增加了VTE概率2.1倍 (OR2.13).
结论:
- 在这项大型前性研究中,高摄入TEGMA值并不能预测VTE.
- 增加的R-时间在入院TEG,表明更长的凝块形成时间,矛盾地与骨科创伤患者的更高的VTE风险有关.
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