基本代谢率作为抗骨质疏松症的保护因素:来自三个国际衰老数据库的多队列纵向研究
Yuzhou Cai1, Fangyi Dai1, Hongyu Li2
1Department of Gastrointestinal Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Frontiers in nutrition
|February 9, 2026
概括
较高的基础代谢率 (BMR) 与老年人患骨质疏松症的风险降低有关,而这与肌肉质量无关. 这种关联是线性的,受教育和吸烟习惯的影响.
科学领域:
- 老年学是一门学科.
- 代谢健康 代谢健康
- 骨健康 骨健康 骨健康
背景情况:
- 骨质疏松症对全球老龄化人口构成重大公共卫生挑战.
- 基础代谢率 (BMR) 与发生骨质疏松症之间的独立关联,不同于肉,需要进一步调查.
研究的目的:
- 调查BMR和骨质疏松症发病率之间的关系.
- 为了确定肉类病状况和人口因素是否会改变这种关联.
主要方法:
- 分析了来自三个纵向队列 (ELSA,HRS,SHARE) 的17,836名45岁以上的成年人.
- 基底代谢率 (BMR) 估计使用米夫林-圣杰尔方程,并分析在四分位数和每标准偏差.
- 考克斯的比例危险模型和受限制的立方线用于评估关联和剂量反应关系,并进行了子组和灵敏度分析.
主要成果:
- 在11.5年的时间里,1490名参与者患有骨质疏松症.
- 较高的BMR四分位数与明显较低的骨质疏松症风险相关 (HR为0.629最高与最低).
- 骨质疏松率的每一个标准偏差增加与骨质疏松症风险降低18% (HR 0.823) 相相关,并观察到线性趋势.
结论:
- 升高的BMR独立地与线性地减少发生骨质疏松症的风险有关,超出了肉症和其他风险因素.
- 在这种关系中,教育和吸烟状况被确定为显著的效果修饰因素.
- 骨质疏松率作为代谢能力的潜在可访问标志物,有助于老年人群的骨质疏松风险分层.
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