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Updated: Feb 10, 2026

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新辅助免疫治疗在可切除非小细胞肺癌中的演变作用:叙述性综述
Zhaoxu Yao1, Bao Sun1, Mingmin Zhang1
1Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Xi'an Medical University, Xi'an, China.
Journal of thoracic disease
|February 9, 2026
概括
新辅助免疫疗法通过改善存活率和减少复发,彻底改变了可切除非小细胞肺癌 (NSCLC) 治疗方法. 这种方法,在手术前进行治疗,现在是标准的护理,提供更好的患者结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 翻译医学是一种翻译医学.
背景情况:
- 切除性非小细胞肺癌 (NSCLC) 的传统治疗包括手术和化疗,往往导致复发.
- 这种方法由于微转移而限制了长期存活.
- 正在出现一种转向新辅助免疫疗法的范式转变.
研究的目的:
- 审查支持新辅助免疫治疗可切除NSCLC的证据.
- 综合最近关键临床试验的发现.
- 讨论生物标志物在指导治疗中的不断变化的作用.
主要方法:
- 这是一本关于PubMed,Embase和Scopus数据库的综合文献综述.
- 包括从2018年到现在的英语文章.
- 专注于II期和III期随机临床试验,使用关键词如"新辅助免疫疗法"",可切除NSCLC"和"生物标志物".
主要成果:
- 新辅助免疫疗法,特别是化疗免疫疗法,现在是可切除NSCLC的标准治疗方法.
- 像CheckMate 816和AEGEAN这样的试验显示了病理完整反应 (pCR),无事件生存 (EFS) 和整体生存 (OS) 的显著改善.
- 新的组合和不断发展的生物标志物 (PD-L1到ctDNA) 正在提高治疗疗效和个性化.
结论:
- 新辅助免疫疗法已经改变了可切除的NSCLC治疗方法,从手术首先转向多式疗法.
- 它提供了改善的长期结果,是现代癌症护理的组成部分.
- 未来的方向包括优化治疗方案,识别预测生物标志物和管理外科手术挑战.
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