在葡萄牙初级保健人口中,他类药物不耐受的患病率:回顾性队列研究
Cristina Gavina1,2,3, Francisco Araújo4, Ana Rita Luz5
1Cardiology Department, Hospital Pedro Hispano, Matosinhos, Portugal.
Journal of lipid and atherosclerosis
|February 9, 2026
概括
达他林不耐受 (SI) 影响9.6%的葡萄牙患者患有动脉样硬化心血管疾病风险,特别是70岁以上的患者. 这凸显了老年人群中替代性降脂疗法的需要.
科学领域:
- 心脏病学 心脏病学
- 初级医疗保健医学 一级医疗保健医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 维他命不耐受 (SI) 在治疗失脂症方面构成了挑战.
- 了解不同人群中的SI患病率对于有效预防心血管疾病至关重要.
研究的目的:
- 估计葡萄牙初级保健机构中他类药物不耐受 (SI) 的患病率.
- 应用CLEAR Outcomes试验纳入标准来进行标准化评估.
主要方法:
- 葡萄牙马托辛霍斯电子健康记录 (EHR) 的回顾性分析 (系统启动2023年12月).
- 包括12393名年龄在18-85岁之间的患者,患有动脉样硬化心血管疾病 (ASCVD) 或高/非常高的ASCVD风险,LDL-C≥100 mg/dL,接受降脂疗法.
- 通过自由文本搜索识别的SI,定义为处方≥2种他类药物或不愿意尝试第二种他类药物.
主要成果:
- 在研究人群中,观察到9.6% (n=1,195) 的患者有类药物不耐受性 (SI).
- 患有SI的患者的平均年龄为73岁,LDL-C的平均值为100mg/dL.
- 年龄较大的个体 (≥70岁) 的SI可能性明显更高 (OR,1.3;95% CI,1.1-1.4).
结论:
- 在这个葡萄牙初级保健人口中,SI的患病率与现有文献一致.
- 在老年人中,SI显著升高,这强调了临床的关键考虑.
- 研究结果强调,有必要探索老年患者的替代性失脂症治疗方法.
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