热带地区的骨和关节感染:高频率的阴性细菌和经验治疗的含义
Carla Pizzinat1, Sylvaine Bastian2,3, Frédéric Desmoulins4
1Department of Infectious Diseases, University Hospital of Guadeloupe, Les Abymes, Guadeloupe, France.
Open forum infectious diseases
|February 9, 2026
概括
格兰阴性菌根 (GNB) 是热带地区骨关节感染 (BJIs) 的主要原因. 当地监测对于指导这些地区BJIs有效的经验性抗生素治疗至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 整形外科 整形外科 整形外科
背景情况:
- 骨关节感染 (BJIs) 是一个日益增长的全球健康挑战.
- 热带地区BJIs的流行病学数据很少.
- 了解致病原体和耐药性模式对于有效治疗至关重要.
研究的目的:
- 在热带环境中对BJIs负责的微生物病原体的特征.
- 为了确定这些致病剂的抗生素耐药性模式.
- 为加勒比海地区的BJIs提供经验性抗生素治疗策略的信息.
主要方法:
- 在瓜德罗普大学医院进行了为期6年的回顾性研究 (2019-2024年).
- 包括第一个微生物学确认的BJI发作的成年患者.
- 分析了来自312名患者的449个分离物.
主要成果:
- 格拉姆阴性细菌 (GNB) 是主要的分离物 (41%),包括产生AmpCβ-lactamase的肠杆菌和Pseudomonas aeruginosa.
- 甲素耐药的金黄色葡萄球菌占隔离物的3%.
- 在各种BJI类型中经常发现GNB,骨质炎和骨质合成相关感染的患病率更高.
- 与GNB感染相关的因素包括咬伤/伤和与土壤接触.
- 抗生素敏感性各不相同,而塞法林在某些BJI类型中,与塞费皮姆和皮佩拉林-塔扎巴克坦相比,有效性有限.
结论:
- 在热带环境中的BJIs中,グラム阴性细菌扮演着重要的角色.
- 当地监测系统对于指导实证抗生素选择至关重要.
- 建议根据局部耐药性模式定制治疗策略.
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