在患有血液性恶性瘤的患者中对月经抑制的考虑
Sahaana Veeravalli1, Allison Schepers1, Lydia L Benitez1
1Department of Pharmacy, University of Michigan Health, Ann Arbor, Michigan, USA.
Pharmacotherapy
|February 9, 2026
概括
患有血液性恶性瘤的患者面临严重的月经出血风险. 这篇评论详细介绍了月经抑制的选择,如GnRH激动剂和激素避孕药,用于治疗癌症患者的出血.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 妇科 妇科 妇科 妇科
背景情况:
- 接受化疗的血液性恶性瘤患者患有严重阴道出血的风险增加.
- 由于恶性瘤和骨髓抑制性化疗引起的血小板减少,加剧了这种出血风险.
- 在这个脆弱的患者群体中,大量的月经出血会导致显著的发病率,需要主动管理.
研究的目的:
- 对血液恶性瘤患者的可用预防性月经抑制药物进行审查.
- 讨论影响选择月经抑制方法的因素.
- 提出一种系统的方法,根据患者特定的特征选择最佳药物.
主要方法:
- 对血液恶性瘤患者月经抑制现有证据的文献综述.
- 分析不同类型的药物:淋巴激素释放激素激动剂,仅孕激素治疗和组合激素避孕药.
- 评估影响药物选择的因素,包括疗效,出血状态,避孕需求和血栓风险.
主要成果:
- 抑制月经是这些患者的支持性护理的关键组成部分.
- 可用的选择包括GnRH激动剂,仅含孕激素的药物和组合激素避孕药,每个都有不同的配置.
- 选择标准包括平衡疗效,急性出血管理,避孕要求和血栓风险评估.
结论:
- 适当选择的月经抑制对于降低患有血液性恶性瘤的患者的发病率至关重要.
- 一种有条不的,以患者为中心的方法是必要的,以应对药物选择的复杂性.
- 进一步的研究可能会完善在这个人群中最佳月经管理的指南.
相关概念视频
The Menstrual Cycle
3.8K
The menstrual cycle is a recurrent sequence of changes in the uterine endometrium, specifically its functional layer, the stratum functionalis. This cycle prepares the uterus for potential pregnancy. This cycle typically spans 21–35 days, averaging 28 days, and aligns with the ovarian cycle, regulated by fluctuating levels of ovarian hormones, primarily estrogen and progesterone.
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
The menstrual phase occurs from days 1 to 5 and involves the shedding of the stratum functionalis, as a...
3.8K
Hormonal Regulation of the Menstrual Cycle
1.7K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.7K
Design Consideration
583
Designing a structure involves a series of considerations, primarily the material's ultimate strength, calculated through tests that measure changes under increased force until the material reaches its breaking point or limit. The ultimate load, where the material breaks, is divided by its original cross-sectional area, resulting in the ultimate normal stress or strength. The ultimate shearing stress is another significant factor taken into account.
The factor of safety is another key...
The factor of safety is another key...
583
Tensile Strength Considerations of Concrete
558
Considering the tensile strength of concrete involves recognizing that the theoretical strength of cement paste can be up to a thousand times higher than what is observed in practical applications. This significant discrepancy is largely attributed to the presence of microscopic cracks within the concrete. These cracks tend to amplify stress at their tips when a load is applied, a phenomenon explained by Griffith's theory of brittle fracture.
The dimensions and shape of a concrete specimen...
The dimensions and shape of a concrete specimen...
558
Transmission Line Design Considerations
633
Aluminum has become the material of choice for overhead transmission lines, surpassing copper due to its abundance and cost-effectiveness. The most prevalent type is the aluminum conductor, steel-reinforced (ACSR), which combines aluminum strands around a steel core. Other variants include all-aluminum conductors (AAC), all-aluminum alloy conductors (AAAC), aluminum conductor alloy-reinforced (ACAR), and aluminum-clad steel conductors. Advanced designs, such as aluminum conductors with steel...
633
Special considerations while measuring pulse
981
Assessing a patient's pulse is a fundamental skill in healthcare, but certain situations require special attention:
981


