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相关概念视频

Chromatin Immunoprecipitation- ChIP02:36

Chromatin Immunoprecipitation- ChIP

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Chromatin immunoprecipitation, or ChIP, is an antibody-based technique used to identify sites on DNA that bind to transcription factors of interest or histone proteins. It also helps determine the type of histone modifications such as acetylation, phosphorylation, or methylation.
Types of ChIP
ChIP can be divided into two types - X-ChIP and N-ChIP. X-ChIP involves in vivo cross-linking of histones and regulatory proteins to DNA, fragmenting the DNA by sonication, and isolating the protein-DNA...
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Base Excision Repair01:54

Base Excision Repair

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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
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DNA Base Pairing02:27

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Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,
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In structural engineering, the analysis of beams subjected to varying loads is a critical aspect of understanding the behavior and performance of these structural elements. A common scenario involves a beam subjected to a combination of different load distributions.
Consider a beam of length L subjected to a varying load, which is a combination of parabolic and trapezoidal load distribution along the x-axis. In this case, it is essential to determine the resultant loads, their locations, and...
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In pipe flow analysis, problems are typically categorized into three types — Type I, Type II, and Type III — based on the known parameters and the desired outcome. Each type of problem addresses specific engineering requirements using fluid properties, pipe characteristics, and operational conditions.
In a Type I problem, fluid properties (density and viscosity), pipe characteristics (including diameter, length, and surface roughness), and the flow rate or average velocity are...
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Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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Microfluidic Chip Fabrication and Method to Detect Influenza
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基于EGOFET的适应传感器的单芯片多目标检测.

Elena Yu Poimanova1, Elena A Kretova1, Anna K Keshek1,2

  • 1Enikolopov Institute of Synthetic Polymeric Materials of Russian Academy of Sciences, Profsoyuznaya Str. 70, 117393, Moscow, Russian Federation.

Journal of materials chemistry. B
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概括
此摘要是机器生成的。

这项研究引入了aptamer修改的电解质门场效应晶体管 (EGOFETs) 用于多目标检测. EGOFETs可以使用单个aptamer识别元素检测pH值,银离子和流感A病毒.

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科学领域:

  • 生物医学工程 生物医学工程
  • 纳米科学是一个纳米科学.
  • 分子生物学分子生物学

背景情况:

  • 液体多传感器对于各种应用至关重要.
  • 将多个传感器集成到单个芯片上是一个活跃的研究领域.
  • 经过Aptamer修改的电解质接场效应晶体管 (EGOFET) 提供了敏感生物传感的潜力.

研究的目的:

  • 开发基于EGOFET的传感器,用于单芯片多目标检测.
  • 为了利用具有pH依赖的形状切换的体,来感知多个分析物.
  • 证明使用单一识别元素来区分不同目标的可行性.

主要方法:

  • 制造由阿普坦尔修饰的EGOFETs.
  • 使用具有i-动机DNA结构,表现出pH取决于形状变化的aptamer.
  • 研究EGOFET对pH值变化,银离子 (Ag+) 和A型流感病毒的反应.

主要成果:

  • EGOFET表现出对胺体形状变化的敏感性.
  • 传感器通过依赖H+的i-motif组件检测到6-8范围内的pH值变化.
  • 该设备根据独特的EGOFET信号区分pH,Ag+离子和流感A病毒.
  • 在唾液和血等生物液中成功应用得到证实.

结论:

  • 通过使用具有单个识别元件的EGOFET实现了单芯片多目标检测的概念验证.
  • 这项工作为管理基于EGOFET的生物传感器属性铺平了道路.
  • 它为在EGOFET平台上开发先进的单芯片多传感器奠定了基础.