Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

9.7K
Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
9.7K
Interference and Diffraction02:18

Interference and Diffraction

52.5K
Interference is a characteristic phenomenon exhibited by waves. When two electromagnetic waves interact with their peaks and troughs coinciding, a resulting wave with enhanced amplitude is produced. This is known as constructive interference. In this case, the two waves interacting are in phase with each other.
52.5K
RNA Interference01:23

RNA Interference

28.2K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.2K
Adhesion01:14

Adhesion

44.5K
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow...
44.5K
Cell Adhesion in Plants01:14

Cell Adhesion in Plants

3.4K
Plants have rigid cell walls that are made up of cell wall polysaccharides that mediate cell-cell adhesion. The primary cell walls of plants consist of two independent and interacting polysaccharide networks: a pectin matrix that embeds the second network comprising cellulose and hemicelluloses.
Pectins are complex heteropolymers mainly composed of negatively-charged α-D-glucopyranosyl uronic acid and some neutral glycosyl residues such as α-L-rhamnopyranose, α-L-arabinofuranose,...
3.4K
Metastasis02:30

Metastasis

6.6K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

RIPK4 is associated with altered bioenergetics and invasive in melanoma three-dimensional models.

Scientific reports·2026
Same author

Cholesterol content and membrane properties in metastatic melanoma compared to primary melanoma: an EPR-based study.

International journal of radiation biology·2026
Same author

Mitochondrial Dynamics Participate in an Early Metabolic Adaptation of Glioblastoma Multiforme T98G Cells to Doxorubicin-Induced Chemotherapeutic Stress.

Cells·2026
Same author

Pmel17 Deficiency Affects Melanogenesis and Promotes Tumor Vascularization.

International journal of molecular sciences·2026
Same author

Hydrogen Sulfide Inhibits <i>H. pylori</i>-Induced Gastric Fibroblast Activation: Implications for Cancer Prevention.

Cells·2026
Same author

Targeting Cancer with Redox Catalysis: Manganese Porphyrins and Ascorbate Synergistically Induce Selective Oxidative Stress and Necrotic Cell Death.

Cancers·2025

相关实验视频

Updated: Feb 10, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.9K

RIPK4功能干扰黑色素瘤细胞粘附和转移.

Norbert Wronski1,2, Sławomir Lasota3, Ewelina Madej1

  • 1Department of Biophysics and Cancer Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

Molecular oncology
|February 9, 2026
PubMed
概括

受体相互作用蛋白激酶4 (RIPK4) 驱动黑色素瘤转移. 通过重新编程黑色素瘤细胞的粘附和运动性,RIPK4的损失显著减少了肺转移,使RIPK4成为黑色素瘤进展的关键调节者.

关键词:
在RIPK4中使用RIPK4.蜜蜂的迁徙 蜜蜂的迁徙肺部转移是肺部转移的原因之一.黑色素瘤是一种黑色素瘤.重编程是重新编程.

更多相关视频

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

21.8K
Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry
09:52

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Published on: November 25, 2011

16.4K

相关实验视频

Last Updated: Feb 10, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

2.9K
Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

Published on: March 13, 2013

21.8K
Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry
09:52

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Published on: November 25, 2011

16.4K

科学领域:

  • 在瘤学瘤学.
  • 分子生物学分子生物学
  • 癌症研究 癌症研究

背景情况:

  • 受体相互作用蛋白激酶4 (RIPK4) 与各种癌症有关.
  • 在非黑色素瘤的皮肤癌中,RIPK4作为瘤抑制剂,但在黑色素瘤中作为瘤基因.
  • 转移性黑色素瘤中RIPK4水平升高表明在疾病进展中发挥了作用.

研究的目的:

  • 研究RIPK4在黑色素瘤细胞入侵和转移中的作用.
  • 了解RIPK4影响黑色素瘤细胞表型的分子机制.
  • 评估向RIPK4在黑色素瘤中的治疗潜力.

主要方法:

  • 临床样本和体内异种移植模型的综合分析.
  • 使用下一代测序进行转录基因分析.
  • 使用3D球形和基于原的入侵试验进行功能验证.

主要成果:

  • 在体内,RIPK4的删除显著减少了肺转移的形成.
  • RIPK4的损失导致了与粘附和运动相关的基因的转录重编程.
  • RIPK4淘汰细胞显示出运动和入侵能力受损,尽管有一些阿米体表型特征.
  • 重新表达RIPK4恢复了间细胞形态和迁移能力.

结论:

  • RIPK4是黑色素瘤入侵和转移的关键调节者.
  • RIPK4影响晚期的转移性事件,包括扩散和殖民.
  • 失去RIPK4功能会诱导补偿性细胞变化,而这些变化并不能完全恢复侵入性潜力.