基于Cu (II) 和Zn (II) 基协调聚合物的分歧:对黑色素和酸盐的感知,以及它们的抗癌活性
Koushik Saha1, Sunandita Bhar2, Narayan Ch Jana3
1Department of Chemistry, Jadavpur University, Kolkata, West Bengal 700032, India.
ACS applied bio materials
|February 9, 2026
概括
新的铜和协调聚合物 (CPs) 检测出微量二和黑激素. CP1对乳腺癌细胞具有强大的抗癌活性和最小的毒性,具有有前途的诊断和治疗潜力.
科学领域:
- 协调化学 协调化学
- 材料科学 材料科学 材料科学
- 化学传感器 化学传感器
- 生物医学应用 生物医学应用
背景情况:
- 精确检测生物分子,如黑激素和酸盐,对于医学诊断至关重要.
- 协调聚合物 (CPs) 为传感和治疗应用提供可调节的特性.
- 基于铜 (II) 和 (II) 的CP正在被探索,因为它们在检测关键生物分析物中的潜力.
研究的目的:
- 设计和合成新的Cu (II) 和Zn (II) 协调聚合物 (CP).
- 评估这些CP的黑激素和酸盐的感应能力.
- 评估合成CP的抗癌活性和细胞毒性.
主要方法:
- 两种协调聚合物的合成和结构特征: [Cu24]n (CP1) 和 [Zn4]n (CP2).
- 使用光光谱学评估CP1基于光的酸盐 (Trp) 和黑激素 (MEL) 的探测.
- 对抗MCF-7细胞的抗癌活性和对正常PBMCs的细胞毒性的评估.
- 密度函数理论 (DFT) 计算,以了解结合亲和和感应机制.
主要成果:
- CP1对三 (LOD 44.65 nM) 和黑激素 (LOD 38 nM) 呈现选择性发光增强,即使在复杂的生物矩阵中,如血清和牛奶.
- CP1对MCF-7乳腺癌细胞具有显著的抗癌活性 (IC50 = 196.8 ± 2.31 nM),对正常细胞的毒性最小.
- CP2没有显示传感性能,DFT计算证实CP1与托芬的结合比CP2更强.
结论:
- 开发的铜协调聚合物 (CP1) 是一种高度选择性和敏感的托和黑激素传感器.
- CP1表现出有希望的抗癌特性,使其成为向癌症治疗的潜在候选人.
- 该研究强调了合理设计的协调聚合物在诊断和治疗方面的潜力.
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