通过深度学习引导的微针传递重新定义瘤血管透性
Jingwei Tian1, Mingsheng Zhu1, Zhenyu Guan2
1Key Laboratory of Bioactive Materials for the Ministry of Education, College of Life Sciences, State Key Laboratory of Medicinal Chemical Biology, and Academy for Advanced Interdisciplinary Studies, Nankai University, Tianjin 300071, China.
微针精确地打开瘤血管,以提高纳米粒子的输送. 这个平台创建了一个选择大小的窗口,改善药物运输,以更好地设计癌症纳米医学.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 血管生物学 血管生物学
背景情况:
- 低透性 (LP) 瘤血管阻碍了纳米药物的有效性.
- 对瘤血管透性的定量理解对于药物输送至关重要.
- 制定克服这些血管障碍的策略至关重要.
研究的目的:
- 为精确的瘤血管调节引入深度学习引导的微针 (MN) 平台.
- 为了增强纳米粒子扩散到瘤中.
- 定量地绘制血管改造和纳米粒子运输的地图.
主要方法:
- 利用微针 (MN) 输送系统进行局部化组胺的管理.
- 将MN系统与nano-ISML 1.1单容器分析框架集成.
- 在多种瘤模型中对血管重塑和纳米粒子运输进行了定量分析.
主要成果:
- 通过MN进行局部化组胺输送,选择性地扩大内皮结,增加内皮间隙.
- 将LP瘤重新编程为具有高透性的表型,增强纳米颗粒扩散.
- 建立了一个取决于尺寸的透性窗口,允许纳米颗粒≤200nm,但不包括>500nm颗粒.
结论:
- 开发的MN平台使瘤血管结构的控制调节成为可能.
- 这种方法克服了血管障碍,改善了纳米药物输送.
- 跨学科框架为瘤向纳米药物提供了一种机制和预测范式.
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