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Updated: Feb 10, 2026

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
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摩洛哥结核病患者中罕见的STAT1变异:对宿主遗传敏感性的洞察

Sanae Zaidi1,2, Aniss Rafik1,3, Hanaa Skhoun1

  • 1Genetics Unit, Military Hospital Mohammed V, Rabat, Morocco.

Clinical and experimental immunology
|February 9, 2026
PubMed
概括

罕见的STAT1基因变异损害了干扰素- (IFN-γ) 信号通路,削弱了对结核病 (TB) 的免疫防御. 这项研究在摩洛哥结核病患者中发现了八种新的和以前报告的变异,突出了STAT1变异.

关键词:
STAT1;IL-12 - - 一个国家统计数据;在IFN-γγ中.在 silico 研究研究.菌根细菌 (Mycobacteria) 是一种细菌.结核病是一种疾病.

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