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Updated: Feb 10, 2026

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对Corynebacterium glutamicum进行代谢工程,通过精确的白素原合成酶活性调节来增强5-氨基氨酸的产生

Hongyan Zhang1, Caizhi Wei1, Fanglan Ge1

  • 1College of life Sciences, Sichuan Normal University, Chengdu, People's Republic of China.

Applied and environmental microbiology
|February 9, 2026
PubMed
概括

研究人员对Corynebacterium glutamicum进行了改造,以增强5-阿米诺氨酸 (5-ALA) 的产生,这是一个有价值的前体. 通过系统调整基合成酶 (PBGS) 活性,他们实现了创纪录的产量,将5-ALA合成与血红酶代谢脱.

关键词:
5 - 氨基氨基氨基氨基酸.在Corynebacterium glutamicum的研究中,我们发现其他PBGS突变体酶活性调节和代谢效应的影响.高产量应变结构的高产量应变结构.代谢工程是代谢工程.

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