基本的金属基单原子纳米酶用于心肌梗塞治疗疗法.
Ziliang Fu1,2, Xiqing Zhao3,4,5, Yixin Zhang1,2
1Ciechanover Institute of Precision and Regenerative Medicine, School of Medicine, The Chinese University of Hong Kong Shenzhen, Shenzhen, Guangdong, P. R. China.
Advanced healthcare materials
|February 9, 2026
概括
新的单原子纳米酶 (SAzymes) 有效地清除反应性氧物种并激活自然修复通路,为心脏病发作损伤提供有希望的治疗方法并预防心力衰竭.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 心血管研究研究心血管研究
背景情况:
- 心肌梗塞会导致不可逆转的心脏损伤,氧化压力和不良的血管形成,导致心力衰竭.
- 目前的抗氧化剂和再生策略等治疗方法在解决这些复杂问题方面缺乏精度和有效性.
研究的目的:
- 开发一个多功能单原子纳米酶 (SAzyme) 平台,用于精确的时空干预心肌梗塞.
- 研究SAzymes具有原子分散Fe,Cu或Mn中心的治疗潜力,以为的碳框架为中心.
主要方法:
- 在M-N-C框架上制造具有Fe,Cu或Mn中心的单原子纳米酶 (SAzymes).
- 在体外评估SAzyme催化活性 (SOD,催化酶,过氧化酶) 和ROS在缺氧挑战心肌细胞中的清理.
- 在大鼠心肌梗塞模型中对SAzyme疗效的体内评估,包括功能,组织学和毒理学分析.
- 转录组分析以阐明SAzymes激活的金属特异信号通路.
主要成果:
- 铁,和Mn-SA酶证明了广泛的ROS清除,并激活了内源NRF2/HO-1抗氧化途径.
- 输入心脏内SA酶给大鼠,可以保持心脏功能,减少心脏病发作的大小,增强血管生成,减少炎症和纤维化.
- 在SAzyme治疗时没有观察到系统性毒性.
- 转录组分析显示,有明显的金属特异性激活信号通路 (Fe 的PI3K-Akt/NF-κB,Cu 的AMPK/PPAR,Mn 的MAPK/TNF/NF-κB).
结论:
- 微金属SAzymes为治疗缺血性心脏病提供了一种多功能和可调节的纳米医学方法.
- 在SAzymes中的金属的原子身份决定了特定的生物修复途径,使得量身定制的治疗策略成为可能.
- 赛酶代表了一种有前途的进步,超出了对心肌梗塞和相关心力衰竭的传统治疗方法.
相关概念视频
02:32Bonding in Metals
52.6K
Metallic bonds are formed between two metal atoms. A simplified model to describe metallic bonding has been developed by Paul Drüde called the “Electron Sea Model”.
52.6K
03:06Alkali Metals
24.9K
Group 1 elements are soft and shiny metallic solids. They are malleable, ductile, and good conductors of heat and electricity. The melting points of the alkali metals are unusually low for metals and decrease going down the group, while the density increases going down the group with the exception of potassium (Table 1).
Table 1: Properties of the alkali metals
Table 1: Properties of the alkali metals
24.9K
02:37Metallic Solids
20.8K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.8K
02:51Metal-Ligand Bonds
24.4K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
24.4K
02:58Properties of Transition Metals
30.0K
Transition metals are defined as those elements that have partially filled d orbitals. As shown in Figure 1, the d-block elements in groups 3–12 are transition elements. The f-block elements, also called inner transition metals (the lanthanides and actinides), also meet this criterion because the d orbital is partially occupied before the f orbitals.
30.0K
01:33Atomic Structure
210.7K
Overview
210.7K