通过微生物组和精准医学重新编程人类健康
Jhommara Bautista1, Emillie Bazantes-Rodríguez1, Hanah Cedeño1
1Cancer Research Group (CRG), Faculty of Medicine, Universidad de Las Américas, Quito, Ecuador.
Critical reviews in microbiology
|February 9, 2026
概括
人类微生物组通过影响免疫力和新陈代谢,显著影响健康和疾病. 了解和调节这种微生物生态系统为精准医学和疾病预防提供了有希望的途径.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 代谢科学 代谢科学
- 神经生物学 神经生物学 神经生物学
背景情况:
- 人类微生物群,一个庞大的微生物群体,在宿主健康中起着至关重要的作用.
- 它影响免疫力,新陈代谢和神经生物学,影响疾病易感性.
- 微生物组在复杂的宿主环境系统中起作用,影响整体生理学.
研究的目的:
- 审查有益微生物及其代谢物的功能作用.
- 探索失生症的含义及其与各种疾病的联系.
- 讨论基于微生物组的新兴治疗策略.
主要方法:
- 文献综述综合了关于人类微生物组的当前研究.
- 分析多omics技术,有机体模型和计算框架.
- 检查受微生物信号影响的免疫路径.
主要成果:
- 有益的微生物及其代谢物有助于宿主健康.
- 失生症与代谢疾病,炎症,神经发育障碍和癌症有关.
- 针对微生物组的疗法显示出疾病管理的潜力.
结论:
- 微生物组是一个动态的,可修改的器官系统,对健康至关重要.
- 将微生物组作为宿主生理学的一部分,可以实现精确和预防性医学.
- 解决定义微生物健康和治疗植入的挑战至关重要.
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