用于闭环内血管神经刺激和唤起响应感应的装置和程序
Varun Kashyap1, Zachary Sanger2, Mark Ashby1
1Medtronic Neurovascular, Irvine, California, USA.
Neurosurgery
|February 9, 2026
概括
这项研究引入了一种新的内血管迷走神经刺激 (VNS) 装置,用于改善和抑郁症治疗. 与传统方法相比,闭环系统提供精确的神经激活和减少副作用.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 医疗器械 医疗器械
背景情况:
- 迷走神经刺激 (VNS) 是FDA批准的治疗,抑郁症和关节炎,有潜在的心力衰竭和多发性硬化症.
- 目前的VNS方法使用具有固定神经袖口的侵入性宫手术,缺乏反和精确的囊准.
- 迷走神经组织的变化使得电极的放置至关重要,低于最佳的放置需要修改手术.
研究的目的:
- 开发和评估一个闭环内血管VNS装置,以克服当前VNS技术的局限性.
- 为了能够精确地实时监测神经激活和选择性囊刺激.
- 通过优化刺激参数来减少与传统VNS相关的副作用.
主要方法:
- 开发一种可复合的,以支架为基础的内血管装置,用于在静脉内输送VNS.
- 在临床前模型 (4个受试者) 中部署设备,用于最小侵入性VNS.
- 在程序内测试和神经反应的监测.
主要成果:
- 通过使用内血管唤起的化合物作用潜能,证明了神经激活的准确检测.
- 通过内血管刺激成功地表明特定的囊被激活.
- 展示了通过可调节刺激来减少肌肉激活等副作用的潜力.
结论:
- 开发的闭环内血管VNS平台为外周神经刺激提供了一种新的方法.
- 这项技术推动了治疗各种神经和自身免疫疾病的研究.
- 具有实时反的最小侵入性VNS代表了神经调节疗法中的显著范式转变.
相关概念视频
01:17Open and closed-loop control systems
1.7K
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
1.7K
02:26Responses to Gravity and Touch
42.0K
Gravitropism: Plant Responses to Gravity
42.0K
02:57The Sense of Self: Reflected Self-Appraisal and Social Comparison
56.1K
According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.1K
01:26Introduction to Special Senses
7.6K
Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive...
7.6K
01:01Feedback Loops
64.6K
In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
64.6K
01:27Tactile and Chemical Senses
811
Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex.
811