状未破裂内动脉瘤的危险因素:系统性审查和元分析
Maaike J A van Eldik1, Mariam Ali2, Stijn Rietkerken1
1Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
European stroke journal
|February 9, 2026
概括
高血压和吸烟与未破裂的内动脉瘤 (UIAs) 的更高风险有关. 需要更多的研究来了解UIA的性别特异性风险因素,因为目前的数据缺乏分层.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 没有破裂的内动脉瘤 (UIA) 不成比例地影响女性.
- 破裂性动脉瘤会导致脑下关节下出血 (aSAH),但UIA风险因素的理解较少.
- 系统性审查和元分析以确定UIA风险因素并探索性别差异.
研究的目的:
- 确定与囊性UIA存在相关的关键风险因素.
- 评估这些风险因素中潜在的性别差异.
- 为未来的UIA预防和管理研究方向提供信息.
主要方法:
- 对队列,病例控制和横截面研究进行系统审查和元分析.
- 包括到2024年3月发表的研究.
- 分析风险因素,包括吸烟,高血压,酒精使用,糖尿病,高胆固醇血症,体力活动和BMI.
主要成果:
- 分析了21项研究,涉及超过347,000名参与者和8,698例UIA病例.
- 高血压 (OR 1.72) 和吸烟 (OR 1.47) 与增加UIA风险显著相关.
- 对于其他评估的风险因素,没有发现显著的关联;仅有有限的性别分层数据.
结论:
- 高血压和吸烟已被证实是UIAs的风险因素.
- 缺乏性别分层数据,阻碍了对特定性别的UIA风险概况的理解.
- 未来的研究必须包括性别分层分析,以探索女性特有的风险因素.
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