对抗菌素耐药性的担忧不应限制对细菌性传染性疾病预防的多西环林暴露后预防的实施
Fady Mishriky1, Philip A Chan2,1
1Open Door Health, Rhode Island Public Health Institute, Providence, Rhode Island, USA.
概括
多西环素暴露后预防 (doxy-PEP) 有效地减少与男性发生性关系的男性和跨性别女性的梅毒和克拉米迪亚. 关于抗菌素耐药性的担忧不应该阻止doxy-PEP,而是刺激其他地方制四环素过度使用的努力.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 抗微生物药物管理委员会
背景情况:
- 细菌性传播感染 (STIs) 如梅毒,克拉米迪亚和淋病的流行率正在增加.
- 在关键人群中,多西环素暴露后预防 (doxy-PEP) 在预防性传播感染方面表现有前途.
研究的目的:
- 评估doxy-PEP在控制不断上升的性病发病率中的作用.
- 为了解决与doxy-PEP实施相关的抗菌素耐药性 (AMR) 的担忧.
主要方法:
- 对与男性发生性关系的男性 (MSM) 和跨性别女性 (TGW) 的doxy-PEP疗效现有证据的审查.
- 对抗菌素耐药性模式的分析,特别是对尼塞利亚淋病的分析.
- 考虑道德原则,包括公益和公共卫生.
主要成果:
- 多西-PEP有效地减少了MSM和TGW中梅毒和克拉米迪亚的发病率.
- 对淋病预防的可变影响,受局部四环素耐药水平的影响.
- 关于AMR的担忧应该通过有针对性的干预措施来管理,而不是通过限制doxy-PEP来管理.
结论:
- 应该继续实施doxy-PEP,特别是对MSM和TGW,而不会因AMR担忧而受到过度阻碍.
- 减少在畜牧业和其他医疗应用中使用环素的努力至关重要.
- 监测局部AMR,特别是N. gonorrhoeae,必须伴随doxy-PEP的推出,以确保患者的利益和公共卫生的保护.
更多相关视频
09:29In Vivo Investigation of Antimicrobial Blue Light Therapy for Multidrug-resistant Acinetobacter baumannii Burn Infections Using Bioluminescence Imaging
Published on: April 28, 2017
9.9K
09:59Application of the Intelligent High-Throughput Antimicrobial Sensitivity Testing/Phage Screening System and Lar Index of Antimicrobial Resistance
Published on: July 21, 2023
1.8K
相关概念视频
02:27Limiting Reactant
70.3K
The relative amounts of reactants and products represented in a balanced chemical equation are often referred to as stoichiometric amounts. However, in reality, the reactants are not always present in the stoichiometric amounts indicated by the balanced equation.
70.3K
01:28Antimicrobial Effectiveness
1.0K
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
1.0K
01:15Nursing Implementation
6.2K
Implementation is the execution of the nursing care plan developed during the planning phase.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
6.2K
01:29The Number e as a Limit
99
The number e is a fundamental constant in calculus, playing a central role in describing continuous change, particularly exponential growth. It is most naturally defined through its relationship with the natural logarithm, which is the inverse of the exponential function with base e. This relationship allows e to be characterized using basic principles of differentiation rather than as an arbitrary numerical constant.A key property of the natural logarithm function, ln x, is that its derivative...
99
01:23Antimicrobial Proteins
14.5K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
14.5K
02:59Cancer Prevention
8.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
8.2K