循环肌基因对急性耐力运动的反应及其在免疫调节中的作用:系统性审查和元分析
Miriam Ringleb1,2,3, Fabian Fabritius1, Jakob Godde1
1NeuroPyschoImmunology Research Unit, Department for Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany.
概括
耐力运动显著增加了肌水平,例如介素-6和瘤亡因子-α,它们调节免疫反应. 这些效应受到运动类型,强度和持续时间的影响,提供治疗潜力.
科学领域:
- 运动免疫学 运动免疫学
- 骨肌肉生理学 骨肌肉生理学
- 代谢适应 代谢适应
背景情况:
- 肌基因在运动期间调解新陈代谢和免疫系统之间的通信.
- 耐力运动诱导抗炎适应,但效果因运动参数而异.
- 了解肌基因反应对于优化运动干预至关重要.
研究的目的:
- 为了对耐力训练后肌酸度的变化进行元分析.
- 为了确定运动参数和肌肉激素水平之间的剂量反应关系.
- 为了确定调节肌动因对运动反应的因素.
主要方法:
- 系统的文献搜索耐力运动研究,测量特定的肌 (IL-6,IL-10,IL-1ra,TNF-α等). ) 的情况.
- 包括对健康个体进行的研究,测量运动前和运动后的神经.
- 对每个myokine进行随机效应元分析.
主要成果:
- 观察到IL-6,IL-10,IL-1ra,IL-8,IL-15和TNF-α的显著增加.
- 效应大小从小到中等到非常大.
- 肌基因反应受到运动持续时间,强度,类型,训练状态,性别,年龄和其他因素的调节.
结论:
- 耐力运动显著提高了免疫调节肌肉蛋白度.
- 运动参数,如持续时间,强度和类型,以及个人因素,调节这些反应.
- 通过运动向调节肌基因,对各种疾病具有治疗潜力.
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