在HER2+转移性乳腺癌中使用对比增强脑CT扫描进行主动大脑查
Gaia Griguolo1, Michele Bottosso1, Giusy Landa1
1University of Padua Padova Italy.
概括
在HER2+转移性乳腺癌 (mBC) 患者中,主动大脑CT查减少了症状性大脑转移 (BM) 和提高了表现状态. 这支持常规成像,用于早期检测和更好的结果.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- HER2+转移性乳腺癌 (mBC) 具有大脑转移 (BMs) 的高风险.
- EANO-ESMO的指导方针建议对无症状患者进行主动脑成像.
- 在HER2+mBC中对BM的最佳成像策略仍未确定.
研究的目的:
- 追溯评估对比度增强CT查对症状性BMs的影响.
- 评估主动成像对HER2+mBC患者结局的影响.
主要方法:
- 对148名接受过trastuzumab-pertuzumab和taxane治疗的HER2+mBC患者 (2014-2024) 的回顾性分析.
- 脑部查定义为每年对比度增强的脑部CT扫描,在前2年没有神经症状.
- 将接受查的患者与未接受查的患者之间的结局进行比较.
主要成果:
- 接受查的患者的 BM 累积发病率较高 (30.6% vs 12.3%).
- 然而,查显著降低了症状性肌肉瘤 (0%与9.5%相比),并在诊断时改善了表现状态.
- 在查组 (p=0.057) 观察到总体上较少的BMs趋势.
结论:
- 与对比增强的CT脑查与HER2+mBC中较少的症状性BM相关.
- 积极的成像可能会导致在BM诊断时更好的表现状态.
- 需要进一步的前性研究来优化成像时间和模式.
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