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了解骨代谢生物标志物在月经周期中的变化:系统性审查
Isabel Guisado-Cuadrado1, Nuria Romero-Parra2,3, Paula Recacha-Ponce4
1LFE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Science-INEF, Universidad Politécnica de Madrid, Calle de Martín Fierro, 7, 28040, Madrid, Spain. i.guisadoc@upm.es.
Calcified tissue international
|February 9, 2026
概括
这次审查发现了关于骨代谢生物标志物是否在月经周期 (MC) 中发生变化的不一致的证据. 虽然一些研究表明β-CTX-I的变化,骨质卡尔辛水平在整个MC中似乎稳定.
科学领域:
- 内分泌学 在内分泌学.
- 骨生物学 骨生物学 骨生物学
- 生殖健康 生殖健康
背景情况:
- 骨代谢受性激素的影响,但体内有关月经周期影响的数据不一致.
- 了解这些波动对于解释骨生物标志物结果至关重要.
研究的目的:
- 在健康的女性中,系统地审查有关与月经周期相关的骨再吸收和形成生物标志物的现有文献.
- 评估有关月经周期各阶段骨周转的生化标志物的发现的一致性.
主要方法:
- 在PubMed和Web of Science中按照PRISMA指南进行了系统的文献搜索.
- 包括18项研究,并使用NHLBI质量评估工具进行质量评估.
- 在月经周期各阶段的骨生物标志物 (例如β-CTX-I,骨质卡尔辛) 的数据被提取和分析.
主要成果:
- 在研究设计,阶段分类和结果报告中存在显著的异质性.
- 7项研究中的5项表明,在黄质期内β-CTX-I度较低.
- 在8项研究中,6项研究发现,在整个月经周期内,骨质卡尔水平没有显著变化.
结论:
- 目前的证据不支持在整个月经周期内骨代谢生物标志物波动的一致模式.
- 方法的变化,包括激素验证和参与者特征,可能导致不一致的发现.
- 需要进一步的标准化研究来澄清月经周期和骨周转标记物之间的关系.
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