葡萄糖皮质体介导的星细胞L-乳酸释放驱动慢性术后疼痛通过脊髓神经敏感化
Yuying Li1, Yajie An2, Ying Wu2
1School of Medical Technology and Nursing, Shenzhen Polytechnic University, Shenzhen, 518055, Guangdong, China.
Neurochemical research
|February 9, 2026
概括
慢性手术后疼痛涉及天体细胞衍生的L-乳酸盐. 通过阻断L-乳酸盐的产生或通过葡萄糖皮质体信号释放,可以缓解大鼠的疼痛和神经元过敏.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 细胞生物学 细胞生物学
背景情况:
- 慢性手术后疼痛 (CPSP) 与机械形和脊髓神经元过激动性有关.
- 星细胞衍生的L-乳酸盐调节神经元刺激性和突触可塑性,可能有助于CPSP.
研究的目的:
- 调查天体细胞衍生的L-乳酸盐在CPSP的发展和维护中的作用.
- 阐明潜在的机制,包括葡萄皮质激素和特定信号通路的参与.
主要方法:
- 在使用皮肤/肌肉切割和收缩 (SMIR) 模型的老鼠中诱导CPSP.
- 药理上抑制糖原分解 (DAB),碳酸酸酶 (乙胺) 和sAC (乙醇).
- 脊柱星球细胞和上腺切除术 (ADX) 的化学遗传抑制.
- 评估机械体,L-乳酸盐水平,星球细胞激活和神经元发射率.
主要成果:
- SMIR诱导了持续的机械体,星细胞激活,以及脊柱L-乳酸盐的升高.
- 抑制L-乳酸盐生产/释放途径 (糖原分解,CA,SAC) 和天体细胞特异性抑制的抑制剂改善了全体质和减少了L-乳酸盐.
- 外源L-乳酸盐增加了神经元的发射速度,但没有突触传输,这表明它在内在刺激性中发挥了作用.
- 葡萄糖皮质类药物调解了SMIR诱导的全发性和L-乳酸盐升高,因为ADX取消了这些影响.
结论:
- 来自星细胞的L-乳酸盐通过促进脊髓神经元的过度兴奋性,在CPSP的发病过程中发挥着关键作用.
- 葡萄糖皮质体受体信号传递是手术损伤后脊柱背角中星状细胞L-乳酸盐释放的关键驱动因素.
- 准星状细胞的L-乳酸盐生产或葡萄皮质激素信号传递是管理CPSP的潜在治疗策略.
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