在接受食道癌手术的患者中,白内障指数的预后影响
Tomoki Kaname1, Kotaro Sugawara2, Koichi Yagi1
1Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
卡切西亚指数 (CXI) 预测了接受手术的食道癌症患者的生存率不佳. 低CXI与总体和无疾病生存率较差有关,并可能预测非癌症相关死亡.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 生物标志物 生物标志物
背景情况:
- 卡切西亚指数 (CXI) 是一种新的生物标志物,用于评估癌症患者的炎症,肉症和营养状况.
- 它在接受食道切除术的食道癌 (EC) 患者的预后价值需要评估.
研究的目的:
- 评估Cachexia指数 (CXI) 对接受食道切除术的食道癌 (EC) 患者的整体存活率 (OS) 和无病存活率 (DFS) 的预后影响.
主要方法:
- 对378名经过食道切除术的EC患者进行了回顾性审查.
- 使用骨肌指数,血清白蛋白和中性粒细胞与淋巴细胞的比率计算CXI.
- 使用考克斯的比例危险模型分析了OS和DFS的预测因素.
主要成果:
- 低CXI组与年龄较大,并发病率较高和病理阶段较晚有关.
- 低CXI的患者表现出明显较差的OS和DFS (P<0.001).
- 低CXI独立预测了不良的OS (P = 0.002) 和DFS (P = 0.002),以及与非EC相关的死亡率.
结论:
- 低CXI是EC患者食管切除术后,不论疾病阶段如何,低CXI是不良OS和DFS的独立预测因素.
- 在这些患者中,CXI可以作为预测非EC相关死亡率的有价值工具.
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