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Updated: Feb 10, 2026

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与多次暴露于增强对比度的乳房摄影的急性和延迟对比反应的患病率-来自TOCEM试验的经验
Lin Gu1, Ufara Zuwasti1, McKenna Rigling2
1Department of Radiology, UPMC Magee-Womens Hospital, Pittsburgh, PA, USA.
Journal of breast imaging
|February 9, 2026
概括
与对比度增强的乳房扫描 (CEM) 显示了较低的不良反应率,大多数是轻微的和类似过敏的. 在这个查试验期间,受过培训的员工确保了患者的安全.
科学领域:
- 放射学 放射学是一门学科.
- 医疗成像医学成像
- 在瘤学瘤学.
背景情况:
- 增强对比度的乳房显微镜 (CEM) 是乳腺癌查的一个新兴技术.
- 了解CEM中使用的含的对比剂的安全概况至关重要.
研究的目的:
- 在CEM查期间前性对比剂的急性和延迟不良反应的发生率和特征的前性评估.
- 评估CEM在有乳腺癌病史的女性中的安全性.
主要方法:
- 一个前性查试验,涉及有乳腺癌个人病史的女性.
- 通过自动注射器给静脉注射胺醇,每年进行最多三次CEM查.
- 系统记录所有在对比剂施用后一周内发生的不良事件.
主要成果:
- 总共有3873次对比注射给了1651名女性.
- 观察到的整体对比反应率为0.98% (38/3873),其中0.65%是过敏类反应.
- 类似过敏反应主要是皮肤 (80%) 和一般轻度;延迟反应发生在一个小部分的病例.
- 与之前没有接触过对比剂的女性相比,与以前没有接触过对比剂 (0.42%) 的女性相比,过敏类反应的发生率 (1.96%) 显著更高.
- 对于先前对比反应预先接受药物治疗的患者,没有发现过敏类反应.
结论:
- 在CEM查中,有的对比剂与低发生率的不良反应有关.
- 大多数观察到的反应是轻微的和可控的,特别是在训练有素的工作人员.
- 在高风险人群中,CEM似乎是补充乳腺癌查的安全成像方法.
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