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Updated: Feb 11, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
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一个多阶段免疫能力高的基因工程小鼠模型揭示了乌维黑色素瘤的表型可塑性.

Xiaonan Xu1, Xiaoxian Liu2, Vinesh Jarajapu1

  • 1Moffitt Cancer Center Tampa United States.

Cancer research
|February 9, 2026
PubMed
概括

一种新的小鼠模型精确地模仿了人类毛膜黑色素瘤 (UM) 的进展及其瘤微环境. 这种具有免疫能力的模型有助于研究UM生物学和开发针对这种侵袭性眼癌的新疗法.

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Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
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Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
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A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and...
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