边界切除分类识别了用阿特佐利祖马布和贝瓦西祖马布治疗的不可切除的肝细胞癌转化疗法的候选者
Yasuto Takeuchi1, Masahiko Sue1, Nozomi Miyake1
1Department of Gastroenterology, Okayama University Hospital, Okayama, Japan.
概括
在不可切除的肝细胞癌 (HCC) 中确定转化疗法的最佳候选人至关重要. 该研究发现,将边界切除 (BR) 分类与巴塞罗那诊所肝癌 (BCLC) 阶段准确预测哪些患者从阿特佐利祖马布加贝瓦西祖马布 (ATZ/BEV) 治疗中获益最多.
科学领域:
- 肝胆道手术是肝胆道的手术.
- 在瘤学瘤学.
- 翻译医学是一种翻译医学.
背景情况:
- 转化疗法旨在在不可切除的肝细胞癌 (HCC) 中进行全身治疗后进行治愈治疗.
- 预测HCC转化疗法的资格仍然具有挑战性.
- 阿特佐利祖马布加贝瓦齐祖马布 (ATZ/BEV) 是高级HCC的关键系统疗法.
研究的目的:
- 评估边界切除 (BR) 分类与巴塞罗那诊所肝癌 (BCLC) 阶段系统相结合的实用性.
- 为了确定患有不可切除的HCC患者,在ATZ/BEV治疗后最有可能从转化疗法中受益.
主要方法:
- 一项多中心的回顾性研究,对532名无法切除的HCC患者进行了ATZ/BEV治疗.
- 用BR分类对患者进行分类,并按BCLC阶段分层.
- 使用多变量逻辑回归分析了目标反应率 (ORR),转化率,整体存活率 (OS) 和转化预测因素.
主要成果:
- 在5.9%的患者中进行了转化疗法.
- 在BCLC-C HCC中,转化率在BR1 (15.2%) 显著高于BR2 (2.0%) HCC (p < 0.01),BR1状态独立预测转化 (OR 7.0).
- 在BCLC-C/BR1患者中,转换后的ORR (45.0%) 和良好的生存率最高 (p = 0.015);BR分类在BCLC-B HCC中具有有限的价值. 从BR1到可切除状态的下降阶段比从BR2更频繁.
结论:
- 将BR分类与BCLC分期结合起来,可以确定BCLC-C/BR1患者是ATZ/BEV后转化疗法的最佳候选人.
- 这种方法支持将解剖学和瘤学标准纳入高级HCC治疗干预的系统战略.
关键词:
亚特佐利祖马布 (atezolizumab) 和贝瓦西祖马布 (bevacizumab) 是一个复合剂.巴塞罗那诊所肝癌阶段 巴塞罗那诊所边界切除分类的边界切除分类转换疗法的转换疗法.肝细胞癌是肝细胞癌.更多相关视频
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