儿童尾切除术和随后的精神疾病
Cecilia Arana Håkanson1, Fredrik Stiger2, Nele Brusselaers3,4
1Department of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
PLOS mental health
|February 9, 2026
概括
儿童尾切除术与更高的精神疾病风险和晚年医疗保健使用量的增加有关. 这项研究强调了尾切除对儿童的潜在长期健康后果.
科学领域:
- 胃肠病学和精神病学 在
- 微生物组研究 微生物组研究
- 公共卫生 公共卫生
背景情况:
- 尾是肠道微生物群的储存库,有助于肠道微生物群的恢复.
- 尾切除术,特别是在儿童时期,可能会导致持续的微生物组破坏和相关的健康问题.
- 了解儿童尾切除术对心理健康的长期影响至关重要.
研究的目的:
- 调查儿童尾切除术与随后的精神疾病风险之间的关联.
- 探索儿童尾切除术与精神疾病医疗保健消费之间的关系.
- 评估早期尾切除术的潜在长期健康后果.
主要方法:
- 一项涉及752名儿童尾切除术患者的队列研究与3760名对照进行了匹配.
- 关于精神病诊断,医疗保健访问和精神病药物使用的数据来自瑞典人口登记册.
- 使用了分层的Cox和Poisson回归分析,对抗生素,质子抑制剂和非类固醇抗炎药物使用进行了调整.
主要成果:
- 患有童年尾切除术的个体显著增加了患一般精神疾病 (HR 1.19) 和情感障碍 (HR 1.20) 的风险.
- 在尾切除组中,门诊 (IRR 1.20) 和住院精神病医疗保健访问都更频繁.
- 尾切除术的中位数年龄为11岁,平均随访时间为15.5年.
结论:
- 儿童尾切除术与患精神疾病的风险增加有关.
- 这项研究表明,儿童尾切除术后,精神病医疗保健消费的可能性更高.
- 这些发现表明,在儿童期除尾切除和长期心理健康结果之间存在潜在的联系.
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