检查与更年期有关的自杀倾向:系统性审查
Nayra A Martin-Key1, Erin L Funnell1, Eleanor J Barker2
1Cambridge Centre for Neuropsychiatric Research, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.
PLOS mental health
|February 9, 2026
概括
更年期和自杀倾向之间的关系是复杂的,并未完全理解. 目前的证据是混合的,一些研究表明在绝经前期存在联系,而另一些研究发现没有关联,强调需要更多的研究.
科学领域:
- 生殖健康 生殖健康
- 心理健康 心理健康
- 流行病学 流行病学
背景情况:
- 自杀是全球主要的死亡原因,女性遇到更多的尝试,中年女性的死亡率最高.
- 更年期和自杀倾向之间的潜在联系需要进行调查,因为中年女性的自杀率较高.
- 现有关于更年期和自杀倾向的文献需要进行全面的综合来澄清这种关系.
研究的目的:
- 系统地审查有关更年期和自杀倾向之间的关系的现有文献.
- 综合当前关于更年期阶段及其与自杀念头和行为的关联的证据.
- 识别当前研究环境中的差距和局限性.
主要方法:
- 在2023年10月的主要数据库 (MEDLINE,Cochrane,Scopus,Web of Science,PsycINFO,Embase) 进行系统的文献搜索.
- 由两位作者独立选标题,摘要和全文,通过讨论解决差异.
- 使用多种设计研究质量评估工具 (QATSDD) 和叙事/表格数据总结进行偏差风险评估.
主要成果:
- 总共有28项研究符合纳入标准,揭示了更年期和自杀倾向之间复杂而往往矛盾的关系.
- 一些研究表明,在绝经前期更高的自杀念头,而另一些研究发现,绝经后或绝经前的个体,或那些有原发性卵巢缺陷的人,自杀性增加.
- 关键的是,几项研究发现荷尔蒙状况和自杀倾向之间没有显著的联系,一个一致的方法缺陷是缺乏体验参与.
结论:
- 目前关于更年期和自杀倾向之间的关系的证据基础是混合的和不确定的.
- 绝经前期,绝经后期和绝经前期的阶段在不同研究中都显示出与自杀倾向的不同关联.
- 进一步进行高质量的研究,结合实践经验,对于阐明更年期和自杀倾向之间的复杂相互作用至关重要.
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