减肥对精神分裂症谱系疾病中大脑年龄的影响
Vittal Korann1,2, Nicolette Stogios1,2, Karen Marie Sandø Ambrosen3
1Institute of Medical Science, University of Toronto, Toronto, Canada.
PLOS mental health
|February 9, 2026
概括
患有精神分裂症谱系障碍的肥胖患者经历了显著的体重减轻. 这种体重减轻与大脑年龄差距估计的增加正相关,表明潜在的大脑衰老影响.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 精神分裂症谱系障碍 (SSD) 经常与肥胖和2型糖尿病等代谢疾病并发.
- SSD中的肥胖会对大脑健康产生负面影响,但它对大脑解剖学的影响和减肥干预措施的后果仍然未得到充分研究.
研究的目的:
- 为了研究体重减轻和脑部解剖学变化之间的关系,在SSD和并发性肥胖症患者中.
- 评估药理减肥干预措施对该人口大脑年龄差距估计的影响.
主要方法:
- 利用了三项减肥干预试验中48名SSD患者的数据.
- 获得的基线和终点数据,包括代谢参数,大脑结构MRI,BMI,认知功能和精神病理学.
- 使用卷积神经网络从T1加权的MRI扫描中计算大脑年龄差距 (brainAGE).
主要成果:
- 在干预后实现显著的BMI降低 (p < 0.001).
- 在认知或精神病理测量方面没有观察到显著变化 (p > 0.05).
- 在BMI降低和brainAGE (p = 0.03) 之间发现了积极的关联,这表明体重减轻与大脑年龄差距的增加有关.
结论:
- 肥胖的SSD显著减肥与大脑年龄差距的增加有关.
- 需要进一步的研究,以了解这一发现对SSD中的大脑健康和衰老的影响.
相关概念视频
Autism Spectrum Disorder
1.2K
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
1.2K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
2.0K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.0K
Schizophrenia
1.0K
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
1.0K
The Electromagnetic Spectrum
65.5K
The electromagnetic spectrum consists of all the types of electromagnetic radiation arranged according to their frequency and wavelength. Each of the various colors of visible light has specific frequencies and wavelengths associated with them, and you can see that visible light makes up only a small portion of the electromagnetic spectrum. Because the technologies developed to work in various parts of the electromagnetic spectrum are different, for reasons of convenience and historical...
65.5K
Biological Causes of Schizophrenia
650
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
650
Line Loss
545
The different configurations of source-load connections include wye (star) and delta connections. The relationship between line and phase voltages and currents varies depending on the configuration. When the source is supplying power, it is transmitted through the wires to the load, and during this transmission, some power is absorbed by the wires, leading to line loss.
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
Line loss impacts power delivery efficiency in a balanced three-phase circuit. The symmetry in such a circuit simplifies the...
545


