与恢复每日分配甲相关的患者和处方者的特征:一个多层次队列研究
Ria Garg1,2,3, Shaleesa Ledlie1,2,3, Daniel McCormack3
1Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada.
PLOS mental health
|February 9, 2026
概括
恢复每日甲剂量的患者更有可能错过之前的剂量或访问急诊室. 大量的阿片类药物激素治疗 (OAT) 处方者也与增加的复发率有关.
科学领域:
- 公共卫生 公共卫生
- 药理学 药理学是指药理学的学科.
- 成 药物 药物 药物 药物
背景情况:
- 随着COVID-19大流行,甲的发放方式发生了变化,包括带回家的剂量,以支持社交距离.
- 研究表明,随着扩大了家用甲获取的机会,治疗延续率有所改善.
- 然而,大多数患者在六个月内恢复了每日分发的甲,影响因素不明.
研究的目的:
- 为了确定患者和处方者相关的特征,与恢复每日发放的甲相关.
- 分析影响过渡回到每日使用甲的因素,以及大流行后的政策变化.
主要方法:
- 加拿大安大略省的一项基于人口的队列研究,包括每天服用甲的患者.
- 多层次离散时间生存模型分析了26周的每日分发甲的回归.
- 包括变量:急诊室的访问,错过的剂量和处方者的数量.
主要成果:
- 58.5%的人在26周内恢复了每日分发的甲.
- 访问急诊室 (HR=1.27) 和之前遗漏的甲剂量 (HR=1.59) 显著增加了返回的危险.
- 大量OAT处方者 (前20百分位) 的处方也增加了回归危险 (HR=1.44).
结论:
- 患者的临床不稳定性指标,如错过剂量和急救诊所,与恢复每日甲有关.
- 在阿片类激素治疗 (OAT) 计划中的处方量是影响患者恢复每日甲分发的重要因素.
- 这些发现凸显了在甲治疗管理中需要考虑患者和处方者因素的必要性.
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