IRF6基因多态性影响非综合性裂唇的易感性与或没有口腔:一个MOOSE合规的元分析
Rubin Sahu1, Subhra Malinee Mishra1, Prasad Nalabothu2,3
1Department of Zoology, Guru Ghasidas Vishwavidyalaya, Bilaspur, India.
概括
这次元分析发现,IRF6基因多态 rs642961和rs2235371与非综合征性裂唇风险有关,有或没有 palatal (CL±P) 风险. 观察到种族特异性影响,特别是在高加索和亚洲人群中.
科学领域:
- 遗传学 遗传学 是一个
- 分子生物学分子生物学
- 公共卫生 公共卫生
背景情况:
- 带有或没有口的非综合性裂唇 (CL±P) 是一种具有复杂病因的常见出生缺陷.
- IRF6基因在面发育中起着至关重要的作用,并与CL±P病变发生有关.
- 了解IRF6基因多态和CL±P风险之间的关联对于遗传咨询和风险评估至关重要.
研究的目的:
- 进行精确的元分析,检查六种IRF6基因多态化与不同族群中CL±P风险之间的关联.
- 为了确定有助于CL±P易感性的特定IRF6变异.
- 探索IRF6多态和CL±P风险之间的关联中的潜在种族特异性差异.
主要方法:
- 进行了对已发表的53项病例控制研究的元分析.
- 计算了聚合的赔率比率 (ORs) 和95%的置信区间 (CI).
- 进行了敏感性分析,出版偏见评估和基于种族的子组分析.
主要成果:
- rs642961的多态性与CL±P的风险增加有关 (OR:1.31;95%CI:1.10-1.55).
- rs2235371的多态性与CL±P的风险显著降低有关 (OR:0.74;95%CI:0.60-0.92).
- rs861019,rs2013162,rs2235373和rs2235375没有与CL±P风险有显著的关联. 观察到种族特异性影响,rs861019增加了白种人的风险,rs642961增加了亚洲人和混合人口的风险,rs2235371减少了白种人的风险.
结论:
- IRF6基因多态 rs642961和rs2235371与CL±P风险有关,有种族特异性的证据.
- 这些发现支持IRF6基因多态性在CL±P病因学中的作用.
- 需要与多样化的队列进行进一步的研究,以充分阐明对IRF6-CL±P协会的种族或人口特定见解.
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