相关实验视频
Updated: Feb 11, 2026

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In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
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方法研究协议的文章:在高级慢性病 (TRACK) 试验中,使用低剂量里瓦洛克萨班治疗心血管疾病的研究设计和基线特征
American journal of nephrology
|February 9, 2026
概括
这项研究研究了低剂量里瓦罗克萨班的研究,用于患有晚期慢性病 (CKD) 或透析的高风险患者. 它旨在确定rivaroxaban是否可以减少心血管事件而不会增加重大出血风险.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 晚期慢性病 (CKD) 4-5期或透析患者面临心血管事件和死亡的风险增加.
- 目前,缺乏对抗凝血剂安全性和有效性的最终随机试验.
研究的目的:
- 评估低剂量里瓦罗克萨班对晚期慢性病或需要透析的末期病患者主要心血管不良事件 (MACE) 的影响.
- 评估低剂量里瓦罗克萨班的安全性,特别关注这一高风险组的重大出血事件.
主要方法:
- 在高级慢性病 (TRACK) 试验中用低剂量里瓦罗克萨班治疗心血管疾病是一项多中心,随机,安慰剂控制的研究.
- 1886名患有慢性脏病4-5期或透析和高心血管风险的参与者被随机分配给每天两次服用里瓦洛克萨班2.5毫克或安慰剂.
- 主要疗效结局:心血管死亡,心肌梗塞,中风或PAD事件的组合. 主要安全结果:严重出血.
主要成果:
- 在2021年1月至2025年7月期间,有1458名参与者被随机选择.
- 研究人口的平均年龄为63.2岁,其中65岁或以上的个体,女性和糖尿病患者的比例很高.
- 有相当数量的参与者患有透析依赖的功能衰竭,在基线时服用阿司匹林.
结论:
- TRACK试验旨在确定低剂量里瓦洛克萨班在预防重大心血管不良事件方面的疗效和安全性.
- 这些发现将为晚期CKD和高心血管风险的患者提供抗凝剂治疗的关键数据.
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