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Updated: Feb 11, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
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MAGIN-GO:基于双图神经网络和基因本体结构结构的蛋白质功能预测

Runxin Li1,2, Wentao Xie2, Zhenhong Shang2

  • 1Yunnan Key Laboratory of Computer Technologies Application, Kunming University of Science and Technology, Kunming, China.

PloS one
|February 9, 2026
PubMed
概括

MAGIN-GO通过使用先进的图形神经网络集成序列和蛋白质-蛋白质相互作用数据来增强蛋白质功能预测. 这种新的方法提高了分子功能,生物过程和细胞组件领域的准确性.

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Structural Protein Function01:56

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Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
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Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Graphs of functions provide a visual representation of how output values change in response to varying inputs. Each point on the graph corresponds to an ordered pair, where the x-coordinate (independent variable) determines the horizontal position and the y-coordinate (dependent variable) determines the vertical position. Linear functions like y = x give a straight line, indicating a constant rate of change.Nonlinear functions display more complex behaviors. Even power functions generate...
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