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基因组中的Zimin模式

Nikol Chantzi1,2, Ioannis Mouratidis1,2, Ilias Georgakopoulos-Soares1,2

  • 1Institute for Personalized Medicine, Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America.

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概括
此摘要是机器生成的。

在人类基因组中,特别是在编码区域中,发现了Zimin avoidmers,没有Zimin单词的k-mers. 这些模式表现出独特的特性,并且在不同的生物体中有所不同.

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科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 齐明单词被定义为具有相同前和后的模式.
  • 预计足够大的字符串包含Zimin单词.
  • 在基因组中,k-mers避免Zimin单词 (Zimin avoidmers) 的存在和特性在很大程度上仍未被探索.

研究的目的:

  • 研究人类基因组中Zimin避开器的发生和特征.
  • 为了分析Zimin avoidmers的分布和基因组定位.
  • 为了在不同的模型生物中比较Zimin avoidmer模式.

主要方法:

  • 在人类参考基因组中分析k-mer模式.
  • 鉴定和特征Zimin避免者.
  • 来自细菌,古生物和真核生物的八种模型生物的比较基因组学.

主要成果:

  • 人类基因组中所有长于104个基对的k-mers都含有Zimin字.
  • 在人类编码和卫星1区域中,Zimin避开器得到了丰富.
  • 这些避免者表现出较低的生殖线插入/删除率.
  • 齐明避虫的基因组密度和定位在物种之间有很大差异,其中 prokaryotes 显示较高的水平和 eukaryotes 较低.
  • 观察到的最长的Zimin avoidmer长度是S. cerevisiae中的115个基对.

结论:

  • 齐米尼避免者在生物体基因组中表现出不均的分布.
  • 它们具有独特的基因组特性,包括减少突变率.
  • 在研究的基因组中,Zimin avoidmers的消失距离比理论上预测的要短.