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Updated: Feb 11, 2026

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
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Published on: October 25, 2019

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一项重要的基因查确定了酵母Mot1作为R环和基因组不稳定性的抑制剂

María E Soler-Oliva1,2, Rocío A Domínguez-Sierra1,2, Hélène Gaillard1,2

  • 1Centro Andaluz de Biología Molecular y Medicina Regenerativa - CABIMER, Consejo Superior de Investigaciones Científicas - Universidad de Sevilla - Universidad Pablo de Olavide, Seville, Spain.

PLoS genetics
|February 9, 2026
PubMed
概括

类似SWI/SNF的蛋白Mot1通过分解称为R环的RNA-DNA杂交物来防止基因组的不稳定. Mot1功能障碍在S阶段损害了DNA复制,突出显示了它在缓解转录复制冲突中的作用.

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