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Updated: Feb 11, 2026

Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
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Published on: October 25, 2019

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军团菌效应蛋白SidG通过准Arp2/3复合体来破坏宿主细胞骨架

Jiayang Liu1, Siyao Liu2, Rundong Shu1

  • 1State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.

PLoS pathogens
|February 9, 2026
PubMed
概括

肺炎菌使用效应剂SidG来破坏宿主细胞细胞骨架构. 这种细菌蛋白质劫持宿主GTPase Rac1以准Arp2/3复合体,促进有效的细菌入侵.

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相关概念视频

Protein Complex Assembly02:41

Protein Complex Assembly

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The intrinsic polarity of cells can be primarily attributed to two factors- i) the asymmetric accumulation of mobile components such are regulatory molecules and subcellular components across the cell and ii) the orientation of polar cytoskeletal filaments that make up the cytoskeletal networks, specifically microfilaments, and microtubules arranged along the axis of polarity. Interactions between the cytoskeletal filaments are crucial for the establishment and maintenance of the polar nature...
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Overview of the Cytoskeleton
The cytoskeleton is a network of protein filaments present within the cell, having three distinct filaments ̶   microfilaments, microtubules, and intermediate filaments. Each has characteristic features that distinguish them, including the dynamics of their assembly and disassembly, mechanical properties, polarity, and the type of molecular motors associated with them. Earlier, they were thought to be present only in eukaryotic cells; however, their...
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