在外科手术治疗巨细胞瘤后,经外科手术时的丹诺苏马布与局部复发之间的关联:元分析
Mohammad Daher1,2, Tarek Nahle1,3, Julia D Visgauss2
1Department of Orthopaedic Surgery, Hotel Dieu de France, Beirut, Lebanon.
The Journal of bone and joint surgery. American volume
|February 9, 2026
概括
在巨细胞瘤 (GCT) 手术中对外术期间使用登苏马布与局部复发 (LR) 的增加有关. 然而,仅在手术前给出的德诺苏马布并没有显著提高LR率,与手术前后联合使用不同.
科学领域:
- 整形瘤学 整形瘤学
- 药理学研究 药理学研究
- 外科手术的结果
背景情况:
- 巨细胞瘤 (GCT) 在手术管理中带来了挑战,局部复发 (LR) 是一个重大问题.
- 由于研究结果相互矛盾,经过GCT手术后经外科手术后的Denosumab在缓解或加剧LR方面的作用仍在争论中.
研究的目的:
- 在GCT患者中进行元分析,评估外科期登苏马布和LR之间的关联.
- 分析手术方法,denosumab剂量和服用时间如何影响LR速率.
主要方法:
- 在PubMed,Cochrane和谷歌学者中进行了系统的文献搜索,遵循PRISMA指南.
- 包括的研究重点是手术治疗的GCT患者的LR和denosumab相关并发症.
- 考虑了治疗III级证据.
主要成果:
- 分析包括了16项研究,包括1551名患者;310人接受了德诺苏马布,1241人作为对照.
- 接受德诺苏马布的患者显示显著更高的LR率 (OR=1.82,p=0.03),特别是在单独切割的情况下 (OR=2.75,p<0.001).
- 在接受了手术前和手术后denosumab治疗的患者中观察到显著增加的LR率 (OR=5.57,p<0.001). 与登诺苏马布相关的并发症发生在6.5%的病例中.
结论:
- 在外科手术期间,特别是在术前和术后联合使用denosumab时,与巨细胞瘤患者的局部复发增加有关.
- 与对照组相比,仅在手术前期使用德诺苏马布并没有显著增加局部复发的风险.
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