在GHSG HD21试验中的MRD-2通过经过验证的循环瘤DNA测序试验来评估
Jan-Michel Heger1, Julia Mattlener2, Helen Kaul3
1Cancer Center Cologne Essen, Germany.
Blood
|February 9, 2026
概括
在霍奇金淋巴瘤 (HL) 患者两次治疗后使用ctDNA测序进行最小残留疾病 (MRD) 评估,有效预测复发风险. 这种方法有助于个性化治疗和改善治疗结果.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
背景情况:
- 目前的霍奇金淋巴瘤 (HL) 治疗旨在尽量减少复发风险和毒性.
- 通过循环瘤DNA (ctDNA) 的最小残留疾病 (MRD) 评估显示了个性化治疗策略的前景.
- 之前的MRD研究在时间,验证和消极性定义方面缺乏标准化.
研究的目的:
- 评估LymphoVista ctDNA测定用于在HL患者两次治疗周期 (MRD-2) 后的MRD监测.
- 为了将MRD-2状态与患者的结果相关联,特别是无进展生存期 (PFS).
- 探索将MRD-2与正子发射断层扫描 (PET-2) 结合起来,以提高风险分层.
主要方法:
- 在GHSG HD21试验的样本上使用了经过验证的LymphoVista ctDNA测序试验.
- 采用一个病例-队列设计,分析两个治疗周期 (MRD-2) 后的MRD状态.
- 应用反向概率权重来调整参考集中的事件数.
主要成果:
- 与MRD-2阴性患者 (82.2%) 相比,MRD-2阳性患者面临的复发风险 (4年PFS: 36.7%) 显著更高.
- 调整后4年PFS率为MRD-2阳性患者的72.2%,MRD-2阴性患者的95.3%.
- 通过结合MRD-2和PET-2结果,建立了三层风险分层:低,中等和高复发风险组.
结论:
- 通过LymphoVista的MRD-2评估,可以在HL中提供早期和准确的结果预后.
- 这种基于ctDNA的方法可以作为一个独立的工具或补充PET-2以改善治疗指导.
- 个性化风险评估可以导致更为定制和有效的霍奇金淋巴瘤管理.
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