相关实验视频
Updated: Feb 11, 2026

Methods to Test Endocrine Disruption in Drosophila melanogaster
Published on: July 3, 2019
暴露于卵泡液中的内分泌干扰化学物质:对辅助生殖技术结果的影响
Yuxin Jiang1, Xiaoyu Long1, Yongxiu Hao1
1State Key Laboratory of Female Fertility Promotion, Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, Peking University Third Hospital, Beijing, China; National Clinical Research Centre for Obstetrics and Gynaecology (Peking University Third Hospital), National Clinical Key Specialty Construction Programme, Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing Key Laboratory of Collaborative Innovation in Frontier Technologies for Population Quality, Beijing, China.
卵泡液中的内分泌干扰化学物质 (EDC) 对辅助生殖技术 (ART) 的结果产生负面影响. 像MECPP和BHT-COOH这样的关键化学物质,特别是结合起来,会降低胚胎发育,特别是在年轻女性身上.
科学领域:
- 生殖毒理学 生殖毒理学
- 环境健康 环境健康
- 不孕症研究 不孕症研究
背景情况:
- 内分泌干扰化学物质 (EDC) 是环境污染物,可能对生殖健康产生不利影响.
- 卵泡液含有反映卵巢微环境和暴露于异生菌的生物标志物.
- 辅助生殖技术 (ART) 为研究环境因素对人类生殖的影响提供了独特的机会.
研究的目的:
- 研究毛囊液中的内分泌干扰化学物质 (EDC) 与辅助生殖技术 (ART) 的结果之间的关联.
- 识别特定的EDC及其与不良ART结果相关的组合.
- 探索患者年龄对这些关联的潜在修改效应.
主要方法:
- 在中国对176名接受ART治疗的妇女进行前性队列研究.
- 使用先进的分析技术在卵泡液中定量76个EDC.
- 统计分析包括通用线性模型和贝叶斯内核机器回归 (BKMR) 来评估关联和相互作用.
主要成果:
- 十五个EDC显示与传统体外受精/细胞内胚胎精子注射 (IVF/ICSI) 结果有负面关联.
- 单基 (2-乙基-5-碳酸) 甲酸 (MECPP) 和3,5-二-三--4-基酸 (BHT-COOH) 一贯与卵细胞和胚胎质量降低有关.
- BKMR揭示了EDC组合,特别是酸盐 (PAE) 和双S (BPS) 对胚胎发育和生化妊娠率的不良影响.
- 年轻女性 (≤33岁) 在EDC和ART结果之间表现出更强烈的负面关联.
结论:
- 较高的卵泡液EDC度与较差的ART结果有关,无论是单独的还是组合的.
- 已确定MECPP,BHT-COOH,PAE和BPS是对ART不良结果的重要贡献者.
- EDC对ART结果的负面影响在年轻女性中更为明显,这表明年龄相关的脆弱性.
更多相关视频
04:14Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
06:40Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization
Published on: October 24, 2025
相关概念视频
Chemical Signaling in the Endocrine System
Lipid-soluble hormones, such as steroid hormones, demonstrate an intracellular action. These hormones traverse cell membranes due to their lipid nature. Once inside the target cell, they...
Endocrine Signaling
Reproductive Cloning
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
What is the Endocrine System?
The Endocrine System
An Overview of the Endocrine System
The endocrine system collaborates...