药理学上的沉默:重新审视非活性代谢物的临床和分子影响

Ahmed M Abd-Eldayem1

  • 1Department of Medical Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt; Department of Basic Sciences, College of Medicine, Fahad Bin Sultan University (FBSU), 15700, Tabuk 71454, Kingdom of Saudi Arabia.

PubMed
概括

传统上被认为是无活性的药物代谢物显著影响药物的作用和毒性. 这篇评论强调了它们在酶抑制,氧化应激和不良反应中的作用,敦促重新评估它们的生物学意义.

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