大麻二醇的胎盘转移和血管活性:注意快速氧化
M S Harhangi1, L Höfert2, A H J Danser3
1Department of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Internal Medicine, Division of Pharmacology and Vascular Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands; Department of Obstetrics and Gynaecology, Division of Obstetrics and Fetal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
European journal of pharmacology
|February 9, 2026
概括
当氧化被阻止时,大麻素 (CBD) 可以转移到胎儿. 这项研究发现,与收缩的THC不同,CBD扩大了胎盘动脉,为怀孕期间使用大麻的风险提供了见解.
科学领域:
- 产科和妇科 产科和妇科
- 药理学 药理学是指药理学的学科.
- 发育生物学 发展生物学
背景情况:
- 怀孕期间使用大麻的数量正在上升,存在诸如胎儿生长限制等潜在风险.
- 虽然Δ9-四化甘醇 (THC) 被广泛研究,但大麻 (CBD) 产品也被使用,胎盘转移是未知的.
研究的目的:
- 为了调查CBD是否通过胎盘转移.
- 为了确定CBD对胎儿胎盘血管系统的影响.
主要方法:
- 一个ex vivo胎盘 perfusion 模型被用于健康的胎盘.
- 使用液体染色学-并联质谱法量化CBD转移.
- CBD和THC的血管反应性通过线-肌谱评估在胆板动脉中.
主要成果:
- 当抗氧化剂存在时,CBD在母体缓冲中迅速氧化,但在存在抗氧化剂时观察到将其转移到胎儿侧 (胎儿/母体比0.32±0.23).
- CBD导致胎盘动脉扩大36±4%,这种效果被CB1和CB2受体对抗剂减弱.
- 这是一种THC诱导的血管收缩.
结论:
- 防止CBD氧化允许胎儿转移.
- CBD会扩大胎盘血管,而THC会导致收缩.
- 这些发现有助于阐明与母亲大麻使用相关的潜在风险.
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