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中枢神经系统中的微纳米塑料:证据,机制和前景

Zhexun Pei¹, Hang Zhong¹, Xiaoqing Li²

¹Department of Neurology, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China.

|February 9, 2026

概括

微型和纳米塑料 (MNP) 可以进入大脑,导致神经毒性和行为问题. 目前的人类研究表明MNP在大脑中存在,但需要更好的方法来证明塑料暴露的危害.

科学领域:

环境科学环境科学
神经科学是一个神经科学.
毒理学毒理学毒理学

背景情况:

环境微型和纳米塑料 (MNP) 对神经健康的关注越来越大.
在各种环境和生物群中越来越多地检测到MNP.

研究的目的:

综合MNP跨血脑屏障 (BBB) 转移的证据.
审查MNP诱导的神经毒性机制和相关的健康结果.
批判性地评估人类研究中MNP在中枢神经系统 (CNS) 的存在.

主要方法:

实验和临床研究的文献综述.
对动物模型的分析表明MNP的神经毒性.
对检测中枢神经系统组织和流体中MNP的人类研究的评估.

主要成果:

MNPs转移BBB,通过氧化应激,神经炎症,线粒体功能障碍和神经递质干扰诱导神经毒性.
动物模型显示MNP诱导的病理和行为缺陷与神经退行,神经发育障碍和精神疾病相关.
新兴的人类研究报告了中枢神经系统组织/流体中的MNP,与BBB完整性,认知功能和中风严重程度相关.

结论:

人类研究中的方法限制和不一致的质量保证/质量控制阻碍了 robust 暴露评估和因果推断.
标准化检测方法和严格的QA/QC对于确定MNP暴露与神经结果之间的因果关系至关重要.
需要可靠的证据来为减轻塑料暴露风险的公共卫生战略提供信息.

关键词:

大脑大脑大脑的大脑大脑人类暴露的人类暴露.微纳米塑料是一种微纳米塑料.神经系统疾病神经系统疾病神经毒性的作用.

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