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全PPAR激动剂贝扎菲布拉特通过抑制LCN2依赖性铁灭菌来缓解牛皮

Rujuan Xin1, Jianbin Zhang2, Yixin Zhang3

  • 1Department of Pharmacy, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China; Department of Pharmacy, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.

Free radical biology & medicine
|February 9, 2026
PubMed
概括

贝扎纤维酸 (BEZ) 治疗可通过抑制细胞死亡途径铁亡,并重编程脂质代谢来缓解牛皮. 这通过抑制Lipocalin-2 (LCN2) 来实现,为炎症性皮肤疾病提供了一种新的治疗策略.

关键词:
贝扎纤维化 贝扎纤维化铁化是铁化的一种.在 LCN2 中, LCN2 是脂质代谢 脂质代谢 是一种牛皮是一种病.

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