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Updated: Feb 11, 2026

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过度表达FXR恢复了NLRP3介导的线粒体和改善了酒精性肝病中的线粒体功能障碍

Jiaqi Chen1, Wenyu Wang1, Xia Li1

  • 1Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian 116044, China.

Free radical biology & medicine
|February 9, 2026
PubMed
概括

过度表达Farnesoid X受体 (FXR) 通过减少炎症和改善线粒体功能来保护免受酒精性肝病的影响. 这项研究揭示了FXR作为酒精性肝病的潜在治疗标.

关键词:
酒精性肝脏疾病 酒精性肝脏疾病法尔内索伊德X受体 (FXR) 是一种线粒细胞衰变 - - 线粒细胞衰变 (mitophagy) 是一种在NLRP3炎症酶体中,NLRP3炎症氧化应激是一种氧化应激.

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